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Six distinct NFκB signaling codons convey discrete information to distinguish stimuli and enable appropriate macrophage responses

Macrophages initiate inflammatory responses via the transcription factor NFκB. The temporal pattern of NFκB activity determines which genes are expressed and thus, the type of response that ensues. Here, we examined how information about the stimulus is encoded in the dynamics of NFκB activity. We g...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Immunity
Main Authors: Adelaja, Adewunmi, Taylor, Brooks, Sheu, Katherine M., Liu, Yi, Luecke, Stefanie, Hoffmann, Alexander
Format: Artigo
Jezik:Inglês
Izdano: 2021
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8184127/
https://ncbi.nlm.nih.gov/pubmed/33979588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2021.04.011
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