A size-shrinkable matrix metallopeptidase-2-sensitive delivery nanosystem improves the penetration of human programmed death-ligand 1 siRNA into lung-tumor spheroids

Given the maturation of small-interfering RNA (siRNA) techniques with nanotechnology, and because overexpression of human programmed death-ligand 1 (PD-L1) is crucial for T cell inactivation and immunosuppression of the tumor microenvironment, application of siRNA–PD-L1 has demonstrated positive pro...

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Detalhes bibliográficos
Publicado no:Drug Deliv
Main Authors: Wen, Jiaolin, Qiu, Neng, Zhu, Zejiang, Bai, Peng, Hu, Mengshi, Qi, Wenyan, Liu, Yan, Wei, Ailin, Chen, Lijuan
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8183518/
https://ncbi.nlm.nih.gov/pubmed/34078185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/10717544.2021.1931560
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