Dynamic imaging of nascent RNA reveals general principles of transcription dynamics and stochastic splice site selection

The activities of RNA polymerase and the spliceosome are responsible for the heterogeneity in the abundance and isoform composition of mRNA in human cells. However, the dynamics of these megadalton enzymatic complexes working in concert on endogenous genes have not been described. Here, we establish...

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Detalhes bibliográficos
Publicado no:Cell
Main Authors: Wan, Yihan, Anastasakis, Dimitrios G., Rodriguez, Joseph, Palangat, Murali, Gudla, Prabhakar, Zaki, George, Tandon, Mayank, Pegoraro, Gianluca, Chow, Carson C., Hafner, Markus, Larson, Daniel R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8183334/
https://ncbi.nlm.nih.gov/pubmed/33979654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2021.04.012
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