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The splicing factor U2AF1 contributes to cancer progression through a noncanonical role in translation regulation
Somatic mutations in the genes encoding components of the spliceosome occur frequently in human neoplasms, including myeloid dysplasias and leukemias, and less often in solid tumors. One of the affected factors, U2AF1, is involved in splice site selection, and the most common change, S34F, alters a...
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| Publicado no: | Genes Dev |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6499322/ https://ncbi.nlm.nih.gov/pubmed/30842218 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.319590.118 |
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