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Kinetic competition during the transcription cycle results in stochastic RNA processing

Synthesis of mRNA in eukaryotes involves the coordinated action of many enzymatic processes, including initiation, elongation, splicing, and cleavage. Kinetic competition between these processes has been proposed to determine RNA fate, yet such coupling has never been observed in vivo on single tran...

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Détails bibliographiques
Auteurs principaux: Coulon, Antoine, Ferguson, Matthew L, de Turris, Valeria, Palangat, Murali, Chow, Carson C, Larson, Daniel R
Format: Artigo
Langue:Inglês
Publié: eLife Sciences Publications, Ltd 2014
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4210818/
https://ncbi.nlm.nih.gov/pubmed/25271374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.03939
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