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Detecting hypoxia in vitro using (18)F-pretargeted IEDDA “click” chemistry in live cells
We have exemplified a pretargeted approach to interrogate hypoxia in live cells using radioactive bioorthogonal inverse electron demand Diels–Alder (IEDDA) “click” chemistry. Our novel (18)F-tetrazine probe ([(18)F]FB-Tz) and 2-nitroimidazole-based TCO targeting molecule (8) showed statistically sig...
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| Publicado no: | RSC Adv |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Royal Society of Chemistry
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8182949/ https://ncbi.nlm.nih.gov/pubmed/34178309 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d1ra02482e |
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