Detecting hypoxia in vitro using (18)F-pretargeted IEDDA “click” chemistry in live cells

We have exemplified a pretargeted approach to interrogate hypoxia in live cells using radioactive bioorthogonal inverse electron demand Diels–Alder (IEDDA) “click” chemistry. Our novel (18)F-tetrazine probe ([(18)F]FB-Tz) and 2-nitroimidazole-based TCO targeting molecule (8) showed statistically sig...

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Udgivet i:RSC Adv
Main Authors: Allott, Louis, Chen, Cen, Braga, Marta, Leung, Sau Fung Jacob, Wang, Ning, Barnes, Chris, Brickute, Diana, Carroll, Laurence, Aboagye, Eric O.
Format: Artigo
Sprog:Inglês
Udgivet: The Royal Society of Chemistry 2021
Fag:
Chemistry
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8182949/
https://ncbi.nlm.nih.gov/pubmed/34178309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d1ra02482e
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