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KDM5A and KDM5B histone-demethylases contribute to HU-induced replication stress response and tolerance
KDM5A and KDM5B histone-demethylases are overexpressed in many cancers and have been involved in drug tolerance. Here, we describe that KDM5A, together with KDM5B, contribute to replication stress (RS) response and tolerance. First, they positively regulate RRM2, the regulatory subunit of ribonucleo...
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| Publicado no: | Biol Open |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Company of Biologists Ltd
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8181900/ https://ncbi.nlm.nih.gov/pubmed/34184733 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/bio.057729 |
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