Efficacy and safety of dihydroorotate dehydrogenase (DHODH) inhibitors “leflunomide” and “teriflunomide” in Covid-19: A narrative review

Dihydroorotate dehydrogenase (DHODH) is rate-limiting enzyme in biosynthesis of pyrimidone which catalyzes the oxidation of dihydro-orotate to orotate. Orotate is utilized in the biosynthesis of uridine-monophosphate. DHODH inhibitors have shown promise as antiviral agent against Cytomegalovirus, Eb...

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Pubblicato in:Eur J Pharmacol
Autori principali: Kaur, Hardeep, Sarma, Phulen, Bhattacharyya, Anusuya, Sharma, Saurabh, Chhimpa, Neeraj, Prajapat, Manisha, Prakash, Ajay, Kumar, Subodh, Singh, Ashutosh, Singh, Rahul, Avti, Pramod, Thota, Prasad, Medhi, Bikash
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier B.V. 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8180448/
https://ncbi.nlm.nih.gov/pubmed/34111397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejphar.2021.174233
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