Efficacy and safety of dihydroorotate dehydrogenase (DHODH) inhibitors “leflunomide” and “teriflunomide” in Covid-19: A narrative review

Dihydroorotate dehydrogenase (DHODH) is rate-limiting enzyme in biosynthesis of pyrimidone which catalyzes the oxidation of dihydro-orotate to orotate. Orotate is utilized in the biosynthesis of uridine-monophosphate. DHODH inhibitors have shown promise as antiviral agent against Cytomegalovirus, Eb...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Eur J Pharmacol
Main Authors: Kaur, Hardeep, Sarma, Phulen, Bhattacharyya, Anusuya, Sharma, Saurabh, Chhimpa, Neeraj, Prajapat, Manisha, Prakash, Ajay, Kumar, Subodh, Singh, Ashutosh, Singh, Rahul, Avti, Pramod, Thota, Prasad, Medhi, Bikash
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier B.V. 2021
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8180448/
https://ncbi.nlm.nih.gov/pubmed/34111397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejphar.2021.174233
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados