Folic acid as placebo in controlled clinical trials of hydroxychloroquine prophylaxis in COVID-19: Is it scientifically justifiable?

Using folic acid (FA) as placebo complicates the interpretation of the findings of few RCTs evaluating safety and efficacy of hydroxychloroquine prophylaxis in COVID-19. FA is found to bind to furin-protease and spike: ACE2 interface of SARS-CoV-2. In clinical studies, FA level was lowest among seve...

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Detalhes bibliográficos
Publicado no:Med Hypotheses
Main Authors: Kaur, Hardeep, Sarma, Phulen, Bhattacharyya, Anusuya, Prajapat, Manisha, Kumar, Subodh, Prakash, Ajay, Medhi, Bikash
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Ltd. 2021
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Correspondence
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7896118/
https://ncbi.nlm.nih.gov/pubmed/33662863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mehy.2021.110539
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