Endoplasmic reticulum chaperone GRP78/BiP is critical for mutant Kras-driven lung tumorigenesis

Lung cancer is the leading cause of cancer mortality worldwide and KRAS is the most commonly mutated gene in lung adenocarcinoma (LUAD). The 78-kDa glucose-regulated protein GRP78/BiP is a key endoplasmic reticulum (ER) chaperone protein and a major pro-survival effector of the unfolded protein resp...

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Pubblicato in:Oncogene
Autori principali: Rangel, Daisy Flores, Dubeau, Louis, Park, Ryan, Chan, Priscilla, Ha, Dat P., Pulido, Mario A., Mullen, Daniel J., Vorobyova, Ivetta, Zhou, Beiyun, Borok, Zea, Offringa, Ite A., Lee, Amy S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8179725/
https://ncbi.nlm.nih.gov/pubmed/33931739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-021-01791-9
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