Oral pharmacokinetics in beagle dogs of the mitragynine metabolite, 7-hydroxymitragynine

BACKGROUND AND OBJECTIVES: 7-Hydroxymitragynine (7-HMG) is an oxidative metabolite of mitragynine, the most abundant alkaloid in the leaves of Mitragyna speciosa (otherwise known as kratom). While mitragynine is a weak partial μ-opioid receptor (MOR) agonist, 7-HMG is a potent and full MOR agonist....

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Detalhes bibliográficos
Publicado no:Eur J Drug Metab Pharmacokinet
Main Authors: Maxwell, Elizabeth A., King, Tamara I., Kamble, Shyam H., Raju, Kanumuri Siva Rama, Berthold, Erin C., León, Francisco, Hampson, Aidan, McMahon, Lance R., McCurdy, Christopher R., Sharma, Abhisheak
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8179724/
https://ncbi.nlm.nih.gov/pubmed/33847897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13318-021-00684-2
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