Metabolism of a Kratom Alkaloid Metabolite in Human Plasma Increases Its Opioid Potency and Efficacy

[Image: see text] Kratom is widely consumed in the United States for self-treatment of pain and opioid withdrawal symptoms. Mitragynine is the most abundant alkaloid in kratom and is a μ-opioid receptor agonist. 7-Hydroxymitragynine (7-HMG) is a mitragynine metabolite that is a more potent and effic...

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Gepubliceerd in:ACS Pharmacol Transl Sci
Hoofdauteurs: Kamble, Shyam H., León, Francisco, King, Tamara I., Berthold, Erin C., Lopera-Londoño, Carolina, Siva Rama Raju, Kanumuri, Hampson, Aidan J., Sharma, Abhisheak, Avery, Bonnie A., McMahon, Lance R., McCurdy, Christopher R.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Chemical Society 2020
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7737207/
https://ncbi.nlm.nih.gov/pubmed/33344889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsptsci.0c00075
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