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Single-molecule analysis of interaction between p53TAD and MDM2 using aerolysin nanopores
Protein–protein interactions (PPIs) are regarded as important, but undruggable targets. Intrinsically disordered p53 transactivation domain (p53TAD) mediates PPI with mouse double minute 2 (MDM2), which is an attractive anticancer target for therapeutic intervention. Here, using aerolysin nanopores,...
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| Publicado en: | Chem Sci |
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| Autores principales: | , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
The Royal Society of Chemistry
2021
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8179679/ https://ncbi.nlm.nih.gov/pubmed/34168813 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d1sc00386k |
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