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A straightforward methodology to overcome solubility challenges for N-terminal cysteinyl peptide segments used in native chemical ligation

One of the main limitations encountered during the chemical synthesis of proteins through native chemical ligation (NCL) is the limited solubility of some of the peptide segments. The most commonly used solution to overcome this problem is to derivatize the segment with a temporary solubilizing tag....

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Detalhes bibliográficos
Publicado no:Chem Sci
Main Authors: Abboud, Skander A., Cisse, El hadji, Doudeau, Michel, Bénédetti, Hélène, Aucagne, Vincent
Formato: Artigo
Idioma:Inglês
Publicado em: The Royal Society of Chemistry 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8179351/
https://ncbi.nlm.nih.gov/pubmed/34164087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0sc06001a
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