Phenformin promotes keratinocyte differentiation via the calcineurin/NFAT pathway

Phenformin is a drug in the biguanide class that was previously used to treat type 2 diabetes. We have reported the anti-tumor activities of phenformin to enhance the efficacy of BRAF-MEK-ERK pathway inhibition and to inhibit myeloid-derived suppressor cells in various melanoma models. Here we demon...

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Foilsithe in:J Invest Dermatol
Main Authors: Zhou, Qian, Kim, Sun Hye, Pérez-Lorenzo, Rolando, Liu, Chang, Huang, Man, Dotto, Gian Paolo, Zheng, Bin, Wu, Xunwei
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2020
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8179313/
https://ncbi.nlm.nih.gov/pubmed/32619504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jid.2020.05.114
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