Contractility, focal adhesion orientation, and stress fiber orientation drive cancer cell polarity and migration along wavy ECM substrates

Contact guidance is a powerful topographical cue that induces persistent directional cell migration. Healthy tissue stroma is characterized by a meshwork of wavy extracellular matrix (ECM) fiber bundles, whereas metastasis-prone stroma exhibit less wavy, more linear fibers. The latter topography cor...

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Detaylı Bibliyografya
Yayımlandı:Proc Natl Acad Sci U S A
Asıl Yazarlar: Fischer, Robert S., Sun, Xiaoyu, Baird, Michelle A., Hourwitz, Matt J., Seo, Bo Ri, Pasapera, Ana M., Mehta, Shalin B., Losert, Wolfgang, Fischbach, Claudia, Fourkas, John T., Waterman, Clare M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2021
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC8179222/
https://ncbi.nlm.nih.gov/pubmed/34031242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2021135118
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