Contractility, focal adhesion orientation, and stress fiber orientation drive cancer cell polarity and migration along wavy ECM substrates

Contact guidance is a powerful topographical cue that induces persistent directional cell migration. Healthy tissue stroma is characterized by a meshwork of wavy extracellular matrix (ECM) fiber bundles, whereas metastasis-prone stroma exhibit less wavy, more linear fibers. The latter topography cor...

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Enregistré dans:
Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Fischer, Robert S., Sun, Xiaoyu, Baird, Michelle A., Hourwitz, Matt J., Seo, Bo Ri, Pasapera, Ana M., Mehta, Shalin B., Losert, Wolfgang, Fischbach, Claudia, Fourkas, John T., Waterman, Clare M.
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2021
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8179222/
https://ncbi.nlm.nih.gov/pubmed/34031242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2021135118
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