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Construction of chiral α-tert-amine scaffolds via amine-catalyzed asymmetric Mannich reactions of alkyl-substituted ketimines

Stereoselective Mannich reactions of aldehydes with ketimines provide chiral β-amino aldehydes that bear an α-tert-amine moiety. However, the structural variation of the ketimines is limited due to the formation of inseparable E/Z isomers, low reactivity, and other synthetic difficulties. In this st...

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Vydáno v:Chem Sci
Hlavní autoři: Homma, Chihiro, Takeshima, Aika, Kano, Taichi, Maruoka, Keiji
Médium: Artigo
Jazyk:Inglês
Vydáno: The Royal Society of Chemistry 2020
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8179053/
https://ncbi.nlm.nih.gov/pubmed/34163907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0sc05269h
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