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Construction of chiral α-tert-amine scaffolds via amine-catalyzed asymmetric Mannich reactions of alkyl-substituted ketimines

Stereoselective Mannich reactions of aldehydes with ketimines provide chiral β-amino aldehydes that bear an α-tert-amine moiety. However, the structural variation of the ketimines is limited due to the formation of inseparable E/Z isomers, low reactivity, and other synthetic difficulties. In this st...

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Библиографические подробности
Опубликовано в: :Chem Sci
Главные авторы: Homma, Chihiro, Takeshima, Aika, Kano, Taichi, Maruoka, Keiji
Формат: Artigo
Язык:Inglês
Опубликовано: The Royal Society of Chemistry 2020
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC8179053/
https://ncbi.nlm.nih.gov/pubmed/34163907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0sc05269h
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