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Synthesis of 2-oxoglutarate derivatives and their evaluation as cosubstrates and inhibitors of human aspartate/asparagine-β-hydroxylase
2-Oxoglutarate (2OG) is involved in biological processes including oxidations catalyzed by 2OG oxygenases for which it is a cosubstrate. Eukaryotic 2OG oxygenases have roles in collagen biosynthesis, lipid metabolism, DNA/RNA modification, transcriptional regulation, and the hypoxic response. Aspart...
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| Published in: | Chem Sci |
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| Main Authors: | , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
The Royal Society of Chemistry
2020
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8179049/ https://ncbi.nlm.nih.gov/pubmed/34163896 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0sc04301j |
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