CHEK1 and circCHEK1_246aa evoke chromosomal instability and induce bone lesion formation in multiple myeloma

BACKGROUND: Multiple myeloma (MM) is still incurable and characterized by clonal expansion of plasma cells in the bone marrow (BM). Therefore, effective therapeutic interventions must target both myeloma cells and the BM niche. METHODS: Cell proliferation, drug resistance, and chromosomal instabilit...

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Vydáno v:Mol Cancer
Hlavní autoři: Gu, Chunyan, Wang, Wang, Tang, Xiaozhu, Xu, Tingting, Zhang, Yanxin, Guo, Mengjie, Wei, Rongfang, Wang, Yajun, Jurczyszyn, Artur, Janz, Siegfried, Beksac, Meral, Zhan, Fenghuang, Seckinger, Anja, Hose, Dirk, Pan, Jingxuan, Yang, Ye
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2021
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8178856/
https://ncbi.nlm.nih.gov/pubmed/34090465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12943-021-01380-0
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