CHEK1 and circCHEK1_246aa evoke chromosomal instability and induce bone lesion formation in multiple myeloma

BACKGROUND: Multiple myeloma (MM) is still incurable and characterized by clonal expansion of plasma cells in the bone marrow (BM). Therefore, effective therapeutic interventions must target both myeloma cells and the BM niche. METHODS: Cell proliferation, drug resistance, and chromosomal instabilit...

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Bibliografiske detaljer
Udgivet i:Mol Cancer
Main Authors: Gu, Chunyan, Wang, Wang, Tang, Xiaozhu, Xu, Tingting, Zhang, Yanxin, Guo, Mengjie, Wei, Rongfang, Wang, Yajun, Jurczyszyn, Artur, Janz, Siegfried, Beksac, Meral, Zhan, Fenghuang, Seckinger, Anja, Hose, Dirk, Pan, Jingxuan, Yang, Ye
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2021
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8178856/
https://ncbi.nlm.nih.gov/pubmed/34090465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12943-021-01380-0
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