High-throughput discovery and characterization of human transcriptional effectors

Thousands of proteins localize to the nucleus; however, it remains unclear which contain transcriptional effectors. Here, we develop HT-recruit - a pooled assay where protein libraries are recruited to a reporter, and their transcriptional effects are measured by sequencing. Using this approach, we...

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Bibliografiske detaljer
Udgivet i:Cell
Main Authors: Tycko, Josh, DelRosso, Nicole, Hess, Gaelen T., Aradhana, Banerjee, Abhimanyu, Mukund, Aditya, Van, Mike V., Ego, Braeden K., Yao, David, Spees, Kaitlyn, Suzuki, Peter, Marinov, Georgi K., Kundaje, Anshul, Bassik, Michael C., Bintu, Lacramioara
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8178797/
https://ncbi.nlm.nih.gov/pubmed/33326746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2020.11.024
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