m(6)A RNA hypermethylation-induced BACE2 boosts intracellular calcium release and accelerates tumorigenesis of ocular melanoma

Ocular melanoma, including uveal melanoma (UM) and conjunctival melanoma (CM), is the most common and deadly eye cancer in adults. Both UM and CM originate from melanocytes and exhibit an aggressive growth pattern with high rates of metastasis and mortality. The integral membrane glycoprotein beta-s...

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Detalhes bibliográficos
Publicado no:Mol Ther
Main Authors: He, Fanglin, Yu, Jie, Yang, Jie, Wang, Shaoyun, Zhuang, Ai, Shi, Hanhan, Gu, Xiang, Xu, Xiaofang, Chai, Peiwei, Jia, Renbing
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2021
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8178445/
https://ncbi.nlm.nih.gov/pubmed/33601055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2021.02.014
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