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Histone lactylation drives oncogenesis by facilitating m(6)A reader protein YTHDF2 expression in ocular melanoma

BACKGROUND: Histone lactylation, a metabolic stress-related histone modification, plays an important role in the regulation of gene expression during M1 macrophage polarization. However, the role of histone lactylation in tumorigenesis remains unclear. RESULTS: Here, we show histone lactylation is e...

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Publicat a:Genome Biol
Autors principals: Yu, Jie, Chai, Peiwei, Xie, Minyue, Ge, Shengfang, Ruan, Jing, Fan, Xianqun, Jia, Renbing
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2021
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7962360/
https://ncbi.nlm.nih.gov/pubmed/33726814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-021-02308-z
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