The Hippo Pathway Effector YAP Promotes Ferroptosis via the E3 Ligase SKP2

Ferroptosis is a new form of regulated cell death resulting from the accumulation of lipid-reactive oxygen species (ROS). A growing number of studies indicate ferroptosis as an important tumor suppressor mechanism having therapeutic potential in cancers. Previously, we identified TAZ, a Hippo pathwa...

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Bibliografiske detaljer
Udgivet i:Mol Cancer Res
Main Authors: Yang, Wen-Hsuan, Lin, Chao-Chieh, Wu, Jianli, Chao, Pei-Ya, Chen, Kuan, Chen, Po-Han, Chi, Jen-Tsan
Format: Artigo
Sprog:Inglês
Udgivet: 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8178191/
https://ncbi.nlm.nih.gov/pubmed/33707306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-20-0534
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