Sequential CRISPR gene editing in human iPSCs charts the clonal evolution of myeloid leukemia and identifies early disease targets

Human cancers arise through the sequential acquisition of somatic mutations that create successive clonal populations. Human cancer evolution models could help illuminate this process and inform therapeutic intervention at an early disease stage, but their creation has faced significant challenges....

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Pubblicato in:Cell Stem Cell
Autori principali: Wang, Tiansu, Pine, Allison R., Kotini, Andriana G., Yuan, Han, Zamparo, Lee, Starczynowski, Daniel T., Leslie, Christina, Papapetrou, Eirini P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8178190/
https://ncbi.nlm.nih.gov/pubmed/33571445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2021.01.011
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