Sequential CRISPR gene editing in human iPSCs charts the clonal evolution of myeloid leukemia and identifies early disease targets

Human cancers arise through the sequential acquisition of somatic mutations that create successive clonal populations. Human cancer evolution models could help illuminate this process and inform therapeutic intervention at an early disease stage, but their creation has faced significant challenges....

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Publicat a:Cell Stem Cell
Autors principals: Wang, Tiansu, Pine, Allison R., Kotini, Andriana G., Yuan, Han, Zamparo, Lee, Starczynowski, Daniel T., Leslie, Christina, Papapetrou, Eirini P.
Format: Artigo
Idioma:Inglês
Publicat: 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8178190/
https://ncbi.nlm.nih.gov/pubmed/33571445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2021.01.011
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