Sequential CRISPR gene editing in human iPSCs charts the clonal evolution of myeloid leukemia and identifies early disease targets

Human cancers arise through the sequential acquisition of somatic mutations that create successive clonal populations. Human cancer evolution models could help illuminate this process and inform therapeutic intervention at an early disease stage, but their creation has faced significant challenges....

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Bibliographic Details
Published in:Cell Stem Cell
Main Authors: Wang, Tiansu, Pine, Allison R., Kotini, Andriana G., Yuan, Han, Zamparo, Lee, Starczynowski, Daniel T., Leslie, Christina, Papapetrou, Eirini P.
Format: Artigo
Language:Inglês
Published: 2021
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8178190/
https://ncbi.nlm.nih.gov/pubmed/33571445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2021.01.011
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