Hypoxia Induced by Cobalt Chloride Triggers Autophagic Apoptosis of Human and Mouse Drug-Resistant Glioblastoma Cells through Targeting the PI3K-AKT-mTOR Signaling Pathway

Glioblastoma multiforme (GBM) is the most aggressive brain tumor. Drug resistance mainly drives GBM patients to poor prognoses because drug-resistant glioblastoma cells highly defend against apoptotic insults. This study was designed to evaluate the effects of cobalt chloride (CoCl(2)) on hypoxic st...

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Detalhes bibliográficos
Publicado no:Oxid Med Cell Longev
Main Authors: Lee, Yuan-Wen, Cherng, Yih-Giun, Yang, Shun-Tai, Liu, Shing-Hwa, Chen, Ta-Liang, Chen, Ruei-Ming
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8177987/
https://ncbi.nlm.nih.gov/pubmed/34136065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2021/5558618
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