Multiplexed proteomics of autophagy-deficient murine macrophages reveals enhanced antimicrobial immunity via the oxidative stress response

Defective autophagy is strongly associated with chronic inflammation. Loss-of-function of the core autophagy gene Atg16l1 increases risk for Crohn’s disease in part by enhancing innate immunity through myeloid cells such as macrophages. However, autophagy is also recognized as a mechanism for cleara...

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Publicado en:eLife
Main Authors: Maculins, Timurs, Verschueren, Erik, Hinkle, Trent, Choi, Meena, Chang, Patrick, Chalouni, Cecile, Rao, Shilpa, Kwon, Youngsu, Lim, Junghyun, Katakam, Anand Kumar, Kunz, Ryan C, Erickson, Brian K, Huang, Ting, Tsai, Tsung-Heng, Vitek, Olga, Reichelt, Mike, Senbabaoglu, Yasin, Mckenzie, Brent, Rohde, John R, Dikic, Ivan, Kirkpatrick, Donald S, Murthy, Aditya
Formato: Artigo
Idioma:Inglês
Publicado: eLife Sciences Publications, Ltd 2021
Assuntos:
Cell Biology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8177894/
https://ncbi.nlm.nih.gov/pubmed/34085925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.62320
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