Autophagy regulates inflammatory programmed cell death via turnover of RHIM-domain proteins

RIPK1, RIPK3, ZBP1 and TRIF, the four mammalian proteins harboring RIP homotypic interaction motif (RHIM) domains, are key components of inflammatory signaling and programmed cell death. RHIM-domain protein activation is mediated by their oligomerization; however, mechanisms that promote a return to...

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Publicado en:eLife
Autores principales: Lim, Junghyun, Park, Hyunjoo, Heisler, Jason, Maculins, Timurs, Roose-Girma, Merone, Xu, Min, Mckenzie, Brent, van Lookeren Campagne, Menno, Newton, Kim, Murthy, Aditya
Formato: Artigo
Lenguaje:Inglês
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Cell Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6615860/
https://ncbi.nlm.nih.gov/pubmed/31287416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.44452
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