The critical role of Hedgehog-responsive mesenchymal progenitors in meniscus development and injury repair

Meniscal tears are associated with a high risk of osteoarthritis but currently have no disease-modifying therapies. Using a Gli1 reporter line, we found that Gli1(+) cells contribute to the development of meniscus horns from 2 weeks of age. In adult mice, Gli1(+) cells resided at the superficial lay...

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Библиографические подробности
Опубликовано в: :eLife
Главные авторы: Wei, Yulong, Sun, Hao, Gui, Tao, Yao, Lutian, Zhong, Leilei, Yu, Wei, Heo, Su-Jin, Han, Lin, Dyment, Nathaniel A, Liu, Xiaowei Sherry, Zhang, Yejia, Koyama, Eiki, Long, Fanxin, Zgonis, Miltiadis H, Mauck, Robert L, Ahn, Jaimo, Qin, Ling
Формат: Artigo
Язык:Inglês
Опубликовано: eLife Sciences Publications, Ltd 2021
Предметы:
Developmental Biology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC8177886/
https://ncbi.nlm.nih.gov/pubmed/34085927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.62917
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