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Interaction Energetics and Druggability of the Protein-Protein Interaction between Kelch-like ECH-associated Protein 1 (KEAP1) and Nuclear Factor, Erythroid 2 Like 2 (Nrf2)
Development of small molecule inhibitors of protein-protein interactions (PPI) is hampered by our poor understanding of the druggability of PPI target sites. Here, we describe the application of alanine-scanning mutagenesis, fragment screening, and FTMap-based computational hot-spot mapping to compr...
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| Pubblicato in: | Biochemistry |
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| Autori principali: | , , , , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2020
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8177486/ https://ncbi.nlm.nih.gov/pubmed/31851823 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.9b00943 |
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