The molecular and epigenetic mechanisms of innate lymphoid cell (ILC) memory and its relevance for asthma

Repetitive exposure of Rag1(−/−) mice to the Alternaria allergen extract generated a form of memory that elicited an asthma-like response upon a subthreshold recall challenge 3–15 wk later. This memory was associated with lung ICOS(+)ST2(+) ILC2s. Genetic, pharmacologic, and antibody-mediated inhibi...

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Udgivet i:J Exp Med
Main Authors: Verma, Mukesh, Michalec, Lidia, Sripada, Anand, McKay, Jerome, Sirohi, Kapil, Verma, Divya, Sheth, Dipa, Martin, Richard, Dyjack, Nathan, Seibold, Max A., Knapp, Jennifer R., Tu, Ting-Hui, O’Connor, Brian P., Gorska, Magdalena M., Alam, Rafeul
Format: Artigo
Sprog:Inglês
Udgivet: Rockefeller University Press 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8176441/
https://ncbi.nlm.nih.gov/pubmed/34076685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20201354
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