Luteolin promotes macrophage-mediated phagocytosis by inhibiting CD47 pyroglutamation

‘Don't eat me’ signal of CD47 is activated via its interaction with SIRPα protein on myeloid cells, especially phagocytic cells, and prevents malignant cells from anti-tumor immunity in which pyroglutamate modification of CD47 by glutaminyl-peptide cyclotransferase-like protein (isoQC) takes an...

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Bibliographische Detailangaben
Veröffentlicht in:Transl Oncol
Hauptverfasser: Li, Zhiqiang, Gu, Xuemei, Rao, Danni, Lu, Meiling, Wen, Jing, Chen, Xinyan, Wang, Hongbing, Cui, Xianghuan, Tang, Wenwen, Xu, Shilin, Wang, Ping, Yu, Lei, Ge, Xin
Format: Artigo
Sprache:Inglês
Veröffentlicht: Neoplasia Press 2021
Schlagworte:
Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8176368/
https://ncbi.nlm.nih.gov/pubmed/34051623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tranon.2021.101129
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