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Leukotriene D(4) paradoxically limits LTC(4)-driven platelet activation and lung immunopathology
BACKGROUND: The 3 cysteinyl leukotrienes (cysLTs), leukotriene (LT) C(4) (LTC(4)), LTD(4), and LTE(4), have different biologic half-lives, cellular targets, and receptor specificities. CysLT(2)R binds LTC(4) and LTD(4) in vitro with similar affinities, but it displays a marked selectivity for LTC(4)...
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| 出版年: | J Allergy Clin Immunol |
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| 主要な著者: | , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2020
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8175451/ https://ncbi.nlm.nih.gov/pubmed/33285161 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2020.10.041 |
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