Leukotriene D(4) paradoxically limits LTC(4)-driven platelet activation and lung immunopathology

BACKGROUND: The 3 cysteinyl leukotrienes (cysLTs), leukotriene (LT) C(4) (LTC(4)), LTD(4), and LTE(4), have different biologic half-lives, cellular targets, and receptor specificities. CysLT(2)R binds LTC(4) and LTD(4) in vitro with similar affinities, but it displays a marked selectivity for LTC(4)...

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Publicado en:J Allergy Clin Immunol
Autores principales: Liu, Tao, Barrett, Nora A., Nagai, Jun, Lai, Juying, Feng, Chunli, Boyce, Joshua A.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8175451/
https://ncbi.nlm.nih.gov/pubmed/33285161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2020.10.041
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