In vitro assessment and phase I randomized clinical trial of anfibatide a snake venom derived anti-thrombotic agent targeting human platelet GPIbα

The interaction of platelet GPIbα with von Willebrand factor (VWF) is essential to initiate platelet adhesion and thrombosis, particularly under high shear stress conditions. However, no drug targeting GPIbα has been developed for clinical practice. Here we characterized anfibatide, a GPIbα antagoni...

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Publicado no:Sci Rep
Main Authors: Li, Benjamin Xiaoyi, Dai, Xiangrong, Xu, Xiaohong Ruby, Adili, Reheman, Neves, Miguel Antonio Dias, Lei, Xi, Shen, Chuanbin, Zhu, Guangheng, Wang, Yiming, Zhou, Hui, Hou, Yan, Ni, Tiffany, Pasman, Yfke, Yang, Zhongqiang, Qian, Fang, Zhao, Yanan, Gao, Yongxiang, Liu, Jing, Teng, Maikun, Marshall, Alexandra H., Cerenzia, Eric G., Li, Mandy Lokyee, Ni, Heyu
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8175443/
https://ncbi.nlm.nih.gov/pubmed/34083615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-91165-8
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