A novel snake venom-derived GPIb antagonist, anfibatide, protects mice from acute experimental ischaemic stroke and reperfusion injury

BACKGROUND AND PURPOSE: Ischaemic stroke is a serious disease with limited therapy options. Glycoprotein (GP)Ib binding to von Willebrand factor (vWF) exposed at vascular injury initiates platelet adhesion and contributes to platelet aggregation. GPIb has been suggested as an effective target for an...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Li, Ting-Ting, Fan, Man-Li, Hou, Shi-Xiang, Li, Xiao-Yi, Barry, Devin M, Jin, Hui, Luo, Sheng-Yong, Kong, Feng, Lau, Lit-Fui, Dai, Xiang-Rong, Zhang, Guo-Hui, Zhou, Lan-Lan
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons, Ltd 2015
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4523344/
https://ncbi.nlm.nih.gov/pubmed/25917571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13178
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