The maternal immune response to fetal platelet GPIbα causes frequent miscarriage in mice that can be prevented by intravenous IgG and anti-FcRn therapies

Fetal and neonatal immune thrombocytopenia (FNIT) is a severe bleeding disorder caused by maternal antibody–mediated destruction of fetal/neonatal platelets. It is the most common cause of severe thrombocytopenia in neonates, but the frequency of FNIT-related miscarriage is unknown, and the mechanis...

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Detalhes bibliográficos
Main Authors: Li, Conglei, Piran, Siavash, Chen, Pingguo, Lang, Sean, Zarpellon, Alessandro, Jin, Joseph W., Zhu, Guangheng, Reheman, Adili, van der Wal, Dianne E., Simpson, Elisa K., Ni, Ran, Gross, Peter L., Ware, Jerry, Ruggeri, Zaverio M., Freedman, John, Ni, Heyu
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3204841/
https://ncbi.nlm.nih.gov/pubmed/22019589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI57850
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