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Tight nanoscale clustering of Fcγ receptors using DNA origami promotes phagocytosis
Macrophages destroy pathogens and diseased cells through Fcγ receptor (FcγR)-driven phagocytosis of antibody-opsonized targets. Phagocytosis requires activation of multiple FcγRs, but the mechanism controlling the threshold for response is unclear. We developed a DNA origami-based engulfment system...
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| Udgivet i: | eLife |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
eLife Sciences Publications, Ltd
2021
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8175083/ https://ncbi.nlm.nih.gov/pubmed/34080973 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.68311 |
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