A role for ceramide glycosylation in resistance to oxaliplatin in colorectal cancer

There is growing evidence to support a role for the ceramide-metabolizing enzyme, glucosylceramide synthase (GCS), in resistance to a variety of chemotherapeutic agents. Whether GCS contributes to oxaliplatin resistance in colorectal cancer (CRC) has not yet been determined. We have addressed this p...

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Bibliographic Details
Published in:Exp Cell Res
Main Authors: Madigan, James P., Robey, Robert W., Poprawski, Joanna E., Huang, Huakang, Clarke, Christopher J., Gottesman, Michael M., Cabot, Myles C., Rosenberg, Daniel W.
Format: Artigo
Language:Inglês
Published: 2020
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8175058/
https://ncbi.nlm.nih.gov/pubmed/31972222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yexcr.2020.111860
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