Increased RET Activity Coupled with a Reduction in the RET Gene Dosage Causes Intestinal Aganglionosis in Mice

Mutations of the gene encoding the RET tyrosine kinase causes Hirschsprung’s disease (HSCR) and medullary thyroid carcinoma (MTC). Current consensus holds that HSCR and MTC are induced by inactivating and activating RET mutations, respectively. However, it remains unknown whether activating mutation...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:eNeuro
Prif Awduron: Okamoto, Mitsumasa, Uesaka, Toshihiro, Ito, Keisuke, Enomoto, Hideki
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Society for Neuroscience 2021
Pynciau:
Research Article: New Research
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC8174796/
https://ncbi.nlm.nih.gov/pubmed/33958373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/ENEURO.0534-20.2021
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