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Diminished Ret expression compromises neuronal survival in the colon and causes intestinal aganglionosis in mice
Mutations in the RET gene are the primary cause of Hirschsprung disease (HSCR), or congenital intestinal aganglionosis. However, how RET malfunction leads to HSCR is not known. It has recently been shown that glial cell line–derived neurotrophic factor (GDNF) family receptor α1 (GFRα1), which binds...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2293334/ https://ncbi.nlm.nih.gov/pubmed/18414682 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI34425 |
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