Diminished Ret expression compromises neuronal survival in the colon and causes intestinal aganglionosis in mice

Mutations in the RET gene are the primary cause of Hirschsprung disease (HSCR), or congenital intestinal aganglionosis. However, how RET malfunction leads to HSCR is not known. It has recently been shown that glial cell line–derived neurotrophic factor (GDNF) family receptor α1 (GFRα1), which binds...

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Bibliografiske detaljer
Main Authors: Uesaka, Toshihiro, Nagashimada, Mayumi, Yonemura, Shigenobu, Enomoto, Hideki
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2008
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2293334/
https://ncbi.nlm.nih.gov/pubmed/18414682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI34425
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