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Abuse Potential of Biased Mu Opioid Receptor Agonists
G-protein-biased mu opioid receptor (GPB-MOR) agonists constitute an emerging class of opioid analgesics. The first-in-class GPB-MOR agonist TRV130 (oliceridine) produces typical opioid-like abuse-related effects in rodents and humans. Although GPB-MOR agonists may be safer than conventional opioids...
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| Veröffentlicht in: | Trends Pharmacol Sci |
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| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2018
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8174448/ https://ncbi.nlm.nih.gov/pubmed/30343727 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tips.2018.08.007 |
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