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Effects of Acute and Repeated Treatment with the Biased Mu Opioid Receptor Agonist TRV130 (Oliceridine) on Measures of Antinociception, Gastrointestinal Function & Abuse Liability in Rodents
RATIONALE: TRV130 (oliceridine; N-[(3-methoxythiophen-2-yl)methyl]-2-[(9R)-9-pyridin-2-yl-6-oxaspiro[4.5]decan-9-yl]ethanamine) is a novel mu opioid receptor (MOR) agonist that preferentially activates G-protein vs. β-arrestin signaling pathways coupled to MORs. Prevailing evidence suggests that TRV...
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| Veröffentlicht in: | J Psychopharmacol |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5646680/ https://ncbi.nlm.nih.gov/pubmed/28142305 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0269881116689257 |
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