Lactoferrin Retargets Human Adenoviruses to TLR4 to Induce an Abortive NLRP3-Associated Pyroptotic Response in Human Phagocytes

Despite decades of clinical and preclinical investigations, we still poorly grasp our innate immune response to human adenoviruses (HAdVs) and their vectors. In this study, we explored the impact of lactoferrin on three HAdV types that are being used as vectors for vaccines. Lactoferrin is a secrete...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Front Immunol
Main Authors: Chéneau, Coraline, Eichholz, Karsten, Tran, Tuan Hiep, Tran, Thi Thu Phuong, Paris, Océane, Henriquet, Corinne, Bajramovic, Jeffrey J., Pugniere, Martine, Kremer, Eric J.
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2021
Teme:
Immunology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8173049/
https://ncbi.nlm.nih.gov/pubmed/34093588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.685218
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