Lactoferrin Retargets Human Adenoviruses to TLR4 to Induce an Abortive NLRP3-Associated Pyroptotic Response in Human Phagocytes

Despite decades of clinical and preclinical investigations, we still poorly grasp our innate immune response to human adenoviruses (HAdVs) and their vectors. In this study, we explored the impact of lactoferrin on three HAdV types that are being used as vectors for vaccines. Lactoferrin is a secrete...

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Dades bibliogràfiques
Publicat a:Front Immunol
Autors principals: Chéneau, Coraline, Eichholz, Karsten, Tran, Tuan Hiep, Tran, Thi Thu Phuong, Paris, Océane, Henriquet, Corinne, Bajramovic, Jeffrey J., Pugniere, Martine, Kremer, Eric J.
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2021
Matèries:
Immunology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8173049/
https://ncbi.nlm.nih.gov/pubmed/34093588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.685218
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