Lactoferrin Retargets Human Adenoviruses to TLR4 to Induce an Abortive NLRP3-Associated Pyroptotic Response in Human Phagocytes

Despite decades of clinical and preclinical investigations, we still poorly grasp our innate immune response to human adenoviruses (HAdVs) and their vectors. In this study, we explored the impact of lactoferrin on three HAdV types that are being used as vectors for vaccines. Lactoferrin is a secrete...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Chéneau, Coraline, Eichholz, Karsten, Tran, Tuan Hiep, Tran, Thi Thu Phuong, Paris, Océane, Henriquet, Corinne, Bajramovic, Jeffrey J., Pugniere, Martine, Kremer, Eric J.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8173049/
https://ncbi.nlm.nih.gov/pubmed/34093588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.685218
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