Maximizing the potential of aggressive mouse tumor models in preclinical drug testing

Atypical teratoid rhabdoid tumor (ATRT) is an aggressive embryonal brain tumor among infants and young children. Two challenges exist for preclinical testing in ATRT. First, genetically quiet, ATRT is a difficult tumor to target molecularly. Tumor cells need to divide to propagate tumor growth—inter...

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Udgivet i:Sci Rep
Main Authors: Elghetany, M. Tarek, Ho, Jia-Min, Shi-Qi, Lois Hew, Karthik, Sekar, Su, Jack M. F., Lin, Qi, Du, YuChen, Shen, Jianhe, Chow, Wing-Yuk, Lau, Ching C., Adesina, Adekunle, Major, Angela, Erdreich-Epstein, Anat, Hui, Kam-Man, Li, Xiao-Nan, Teo, Wan-Yee
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8172610/
https://ncbi.nlm.nih.gov/pubmed/34079014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-91167-6
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