EMBR-23. KIF11 DEPENDENCY ON P53 MUTATIONAL STATUS IN MEDULLOBLASTOMA

INTRODUCTION: KIF11, a mitotic kinesin, is a component responsible for assembly and maintenance of mitotic spindle during mitosis. Tumor cells can upregulate KIF11. Inhibition of KIF11 results monopolar spindle formation, resulting in monoastral mitosis in cells. This activates the spindle assembly...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Huang, Shiying, Karthik, Sekar, Lin, Qi, Du, YuChen, Lau, Ching C, Adekunle, Adesina, Su, Jack M F, Major, Angela, Elghetany, M Tarek, Hui, Kam-Man, Li, Xiaonan, Teo, Wan-Yee
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2021
Assuntos:
Embryonal Tumors
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8168209/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noab090.041
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