Molecular Chaperone HSP90 Is Necessary to Prevent Cellular Senescence via Lysosomal Degradation of p14ARF

The tumor suppressor function of p14ARF is regulated at a posttranslational level via mechanisms yet to be fully understood. Here, we report the identification of an unconventional p14ARF degradation pathway induced by the chaperone HSP90 in association with the E3 ubiquitin ligase C-terminus of HSP...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Cancer Res
Main Authors: Han, Su Yeon, Ko, Aram, Kitano, Haruhisa, Choi, Chel Hun, Lee, Min-Sik, Seo, Jinho, Fukuoka, Junya, Kim, Soo-Youl, Hewitt, Stephen M., Chung, Joon-Yong, Song, Jaewhan
Format: Artigo
Sprog:Inglês
Udgivet: 2016
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8170830/
https://ncbi.nlm.nih.gov/pubmed/27793846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-0613
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker